Does gender matter in DND?

Gender is an attribute of a character or other creature in Dungeons & Dragons. Gender typically has no mechanical effect in Dungeons & Dragons, although throughout the game’s history there have been a few exceptions.

https://dungeonsdragons.fandom.com/wiki/Gender#:~:text=Gender%20is%20an%20attribute%20of,have%20been%20a%20few%20exceptions.